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Iran responds by launching missiles and drones towards Israel and four Gulf Arab countries that host US military bases.
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As Iran's second supreme leader, he brutally crushed dissent at home and expanded Iran's footprint abroad, challenging Saudi Arabia for regional dominance.
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Some Iranians said on social media that they were privately mourning the supreme leader. But displays of exuberance broke out in cities across the country.
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Ayatollah Ali Khamenei was killed in an Israeli airstrike on his Tehran compound, according to four Israeli security officials briefed on the matter.
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President Donald Trump announced that Iran's supreme leader, Ayatollah Ali Khamenei, was killed on Saturday after the U.S. and Israel launched a predawn assault.
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Waves of Tomahawk and air-launched missiles eliminate Iranian air defenses and military sites as Trump welcomes the toppling of Khamenei's reign.
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In a phone call today, President Trump said strikes in Iran have caused "very great losses on their leadership," and that "tremendous damage has been inflicted." He told NBC News' Kristen Welker he already thinks the operation is "a success."
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The United States and Israel launched military strikes against Iran overnight. NPR's Mary Louise Kelly discusses the attacks with NPR's Daniel Estrin and Greg Myre.
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President Donald Trump on Saturday said that U.S. and Israeli strikes on Iran killed Ayatollah Ali Khamenei and other top leaders.
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Esmail Baghaei joins ABC News following US and Israeli strikes on Iran early Saturday morning
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