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Many of the suggested cuts, which would require congressional approval, target federal programs that benefit the poor.
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Kennedy has warned of an epidemic of chronic disease, but the budget blueprint would close the C.D.C. center focused on prevention.
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The proposal seeks a cut of $4.5 billion for primary and secondary schools.
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Senators expressed concern with a military budget they said was far too scant, and one objected to the plan's gutting of vital programs, including one that offers home heating assistance for the poor.
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