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It was McCaffrey's first meeting against the Panthers, who traded him to the 49ers in 2022.
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Guard Cade Cunningham and the surging Detroit Pistons, who set an NBA record for consecutive losses in a single NBA season with 28 in 2023, tied a franchise record Monday night with their 13th straight victory, defeating the Indiana Pacers 122-117.
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Tyler Herro eventually got going in his return from ankle surgery in September and led Miami to a win over Dallas on Monday night.
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49ers wide receiver Jauan Jennings responded to a "cheap shot" from Tre'von Moehrig by throwing an open-handed right cross to the Panthers safety's face after the final whistle Monday night.
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Ralph Vacchiano sorts out the NFL's hierarchy after every week of the 2025 season.
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Christian McCaffrey battles his former team in primetime as the 49ers face the Panthers in the Week 12 finale.
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Here are all the latest happenings around the league as we enter the holiday season and the home stretch of the regular season.
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Week 12 was packed with bold statements, sharp sound bites and honest postgame moments.
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Commanders quarterback Jayden Daniels will return to practice this week but is considered a long shot to play versus the Broncos on Sunday night.
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The MRI for Buccaneers quarterback Baker Mayfield revealed a low-grade AC joint sprain in his left shoulder but showed no additional damage, sources told ESPN's Jeremy Fowler on Monday.
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We've got you covered with grades and analysis on every winter signing and big offseason trade.
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Our NFL Nation reporters answer the biggest questions from each game. Here's what we learned from Week 12.
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Miami Heat All-Star guard Tyler Herro is set to make his season debut on Monday against the visiting Dallas Mavericks, the team confirmed.
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The Bucs hit a major detour on their way to another division title, as QB Baker Mayfield is sidelined with a shoulder injury.
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The Saints are bringing in former Ravens kicker Justin Tucker for a tryout, coach Kellen Moore confirmed.
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Shedeur Sanders will remain QB1 in Cleveland for another week, starting for the Browns against the 49ers in Week 13.
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Surprise signings? Slugger or bust? Most impact? We've got a yearbook's worth of awards for the top MLB free agents.
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We're looking ahead to how the 14-team playoff picture could line up en route to Super Bowl LX.
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Dodgers superstar Shohei Ohtani will play for Team Japan in the 2026 World Baseball Classic as the country looks to defend their 2023 title.
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The Los Angeles Lakers signed 6-foot-10 big man Drew Timme to a two-way contract.
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NFL Week 13 is here and we've got the best NFL bets you need to know!
Chris "Bear" Fallica, Geoff Schwartz, and Sammy Panayotovich break down their Top 5 NFL bets to place right now. What's your best bet for Thanksgiving?
If you're looking for NFL Week 13 best bets, betting predictions, picks against the spread, and prop plays, this is your ultimate guide.
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Robert Griffin III joins Colin Cowherd to analyze Shedeur Sanders' first start for the Cleveland Browns, Jaxon Smith-Njigba's record breaking pace, and Caleb Williams & the Chicago Bears' 8-3 record.
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All the free agent options worth adding as we look ahead to Week 13 of the fantasy football season.
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Cowboys left tackle Tyler Guyton is unlikely to play on Thanksgiving against the Chiefs because of a high ankle sprain sustained in the second half of Sunday's game against the Eagles, according to multiple sources.
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What lines offered value once odds came out? Here are six early bets to consider making going into Week 13.
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Every week in fantasy basketball, there are available players who can help fill holes in your roster. Here are the ones to add for the week ahead.
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Dallas was down 21. Detroit was down 10. And Kansas City was down 11. What did we learn as all three rallied in the second half to win their games on Sunday?
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The Mets and Rangers have agreed to a trade that would send second baseman Marcus Semien to New York and outfielder Brandon Nimmo to Texas.
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The Shedeur effect? Maybe, but bettors were on the right side of NFL Week 12 odds, which included backing the Browns. Patrick Everson breaks down the weekend action.
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McCaffrey, one of the best receiving running backs in NFL history, plays his former team on "Monday Night Football."
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The Cowboys' comeback win over the Eagles could turn their season around.
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The Dodgers' two-way star is on the verge of winning his fourth MVP award in five years. Where does his run rank among the all-time best?
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Dodgers star Shohei Ohtani won his fourth MVP in five seasons, all of them in unanimous fashion, beating out the Phillies' Kyle Schwarber and the Mets' Juan Soto for the 2025 NL award.
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Plenty of schools are still chasing their first national championship in program history. Who might be next to accomplish the feat?
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The Lakers have claimed Kostas Antetokoumpo, the younger brother of reigning MVP Giannis Antetokounmpo, off free agency waivers and are expected to assign him to a two-way deal, according to Shams Charania of The Athletic.
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Dellin Betances said that his representative has participated in conversations about a potential contract extension, but after witnessing the birth of his first child, the right-handed reliever said that his energy is focused on helping the Yankees win a World Series title.
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