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Mr. Graham, a four-term incumbent senator, is the favorite to win the general election in a solidly Republican state.
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The vote gave final passage to Republicans' megabill to fund immigration enforcement through the remainder of President Trump's term, clearing it for his signature.
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Nancy Lacore would face a tough fall election in a district drawn in 2021 to be more Republican. She is seeking to replace Representative Nancy Mace, who ran unsuccessfully for governor instead of running for re-election.
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Representative Nancy Mace's run for governor created the opening in the coastal First Congressional District. Republicans are expected to hold it, but one Democrat has proved to be a prolific fund-raiser.
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A mysterious group has spent $500,000 to elevate a progressive candidate in the Democratic primary race for a key House seat.
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Mr. Kiley dropped his Republican affiliation earlier this year. The newly drawn Sixth Congressional District is widely considered to be favorable for Democrats.
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